The future is here
ANTI-SCARRING GENE THERAPY
Cellastra is piondering
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SCARLEXA and VIRLEXA are proprietary gene vectors being developed for human use
Applied as a solution or gel in the wound (SCARLEXA) or inhaled (VIRLEXA) delivers the genetic code for expression and production of anti scarring peptides at the site of injury in skin or lungs, respectively
VIRLEXA FOR MITIGATION OF PANDEMICS SUCH AS COVID-19
VIRLEXA is a formulation for inhalation by hugh risk patients in a pandemic such as COVID-19, e.g.. elderly or other patients wiith risk factors for develop ing long-term complications with fibrosis. An intramuscular injection may potentially prevent multi organ damages.
SCARLEXA TO PREVENT DERMAL SCARRING AFTER BURN INJURIES
Gene therapy for dermal aaplication to revent scarring after burn injury..
Applied topically by spray or ointment suitable for larger body surface area.
SCARLEXA TO PREVENT DERMAL SCARRING AFTER SURGERY
for prevention of dermal scarring after surgery, e.g. breast implant or C-section. Applied as gel before wound closure or injected subcuteneously into the wound area in cosmetically challening areas such as the face, mammoplasty or after C-section..
HOW DOES IT WORK?
SCARLLEXA iand VIRLEXA are formulations of an effective transport vehicle (viral vector)
Programmed with the genetic code for a lactoferrin derived anti-scarring peptide.
Applied under the skin before wound closure after surgery or burn innjuries (SCARLEXA) or inhaled after e. Covid Infection (VIRLEXA) delivers the code for am antiscarring peptide to the targeted cells.
IMay Enable continuous production of anti-scarring peptides in the cells of the wound area for many weeks or months. May Help mitigate hyper immune response (c"ytokine storm"), excessive fibrin formation, secondary infections and excessive scar/ fibrosis formation
THE PEPTIDE DISRUPTS ROOT CAUSES OF SCARRING
1. CONTROLS INFLAMMATION
inflammation promotes severe scarring
2. STIMULATES FIBRINOLYSIS
Bottom: Blocked fibrinolysis promotes scarring.
Top: Reduced blocking increases fibrinolysis and scar resolution
3. FIGHTS INFECTION
infections cause inflammation which increases scar formation