SCIENTIFIC ADVISORY BOARD

LARRY COUTURE, PHD

Scientific Advisor, Gene Therapy

Dr. Couture’s recognized expertise–established over nearly three decades of work with experimental biologics, heavily focused on cell and gene therapies. Until recently he served as the Chair of FDA’s Cellular, Tissue and Gene Therapies Advisory Committee at the time when the first gene therapies were approved. Dr. Couture was a key participant in numerous first-in-man clinical studies, including the first human gene therapy trials, the first direct administration to humans of a genetically engineered virus, and many other cell and gene therapy firsts. He currently serves as CEO of Orbsen Therapeutics, LTD, and Arrogene,Inc. Dr. Couture was the Founding Director and Senior Vice President of the Center for Applied Technology (CAT) at City of Hope where he established and oversaw the offices including Regulatory Affairs, Quality Systems, Technology Licensing and  GMP biologics manufacturing facilities, and directed the successful production of over 300 lots of clinical grade viral vectors, vaccines, plasmid DNA, monoclonal antibodies, and other biological products.  At COH, Dr. Couture oversaw a combined staff of approximately 60 scientists and technical staff and oversaw nearly 50 active INDs .He has also been an ad hoc analyst for venture capital firms and has mentored many start-up companies in the Southern California and the San Francisco Bay Area.

CHRISTOPHER EVANS, PHD

Scientific Advisor, Gene Therapy, Tissue Repair

Professor Evans is a leading expert in the field of tissue repair and new treatment modalities, including gene therapy in arthritis. He is currently Director of the Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, and Professor of Orthopedics, Physical Medicine and Rehabilitation. He previously served as Director of Center for Advanced Orthopedic Studies, Beth Israel Deaconess  Medical Center, Harvard Medical School. and is Maurice Müller Professor of Orthopaedic Surgery Emeritus, Harvard Medical School. Originally from Great Britain, Dr. Evans holds a bachelor's degree in genetics and microbiology, a Ph.D. in biochemistry from the University of Wales, a master's degree in history and philosophy of science from the University of Pittsburgh, and a D.Sc. from the University of Wales. He is the author of more than 300 peer reviewed scientific publications. He served as President Orthopedic Research Society 2004 -2005, and has served as the Chair, Scientific Advisory Board, Journal of Orthopedic Research . In 2009 he won the Marshall R Urist MD Award, Orthopedic Research Society for excellence in tissue regeneration, and in 2010 the Arthur Steidler MD Award, Orthopedic Research Society for understanding of the musculoskeletal system. In 2016 he was elected an inaugural Fellow of International Orthopaedic Research (FIOR)

DR. FOLKE SJOBERG, MD, PHD

Scientific Advisor, Burn Injuries and Tissue Repair

rofessor Sjoberg is a world-renowned, leading expert in the field of burn care/wound healing/tissue repair. He is Professor of Burn Surgery/Critical Care, Department of Clinical and Experimental Medicine (IKE), Linköping University and the Burn Center, Depts. of Hand, Plastic Surgery and Intensive Care, Linköping University Hospital, Linköping, Sweden. Since 2005 he is member Executive Committee of International Society For Burn Injuries and Program Chair since 2011. From 2007 to 2009 he served as President of the European Burns Association and since 2011 he is a board member of the Verification Committee, American Burn Association. He is coauthor of more than 200 peer reviewed publications, eight books. He has supervised 40 PhD students, about 20 dissertations, and served as primary investigator of 150 clinical trials Phase 1-4. He received his MD in 1983, and PhD in 1990, both from Linkoping University. He is a prolific lecturer at conferences around the world, and serves on the editorial board of seven International Journals

PROFESSOR SARAH WOOTTON, PhD

Sr. Scientific Advisor, Virus Molecular Biology

Dr Wootton is an Associate Professor of veterinary virology at the Department of Pathophysiology, Ontario Veterinary College, and Guelph University. She earned her PhD in molecular virology at Guelph University in 2002 and subsequently completed a four year post doc at Fred Hutchinson Cancer Research Center in Seattle. She is a prolific scientist with many dozens of peer reviewed publications and has won numerous awards including City of Guelph's Top 40 under 40 awards and National Sciences and Research Council (NSRC) award for seven consecutive years. The overarching goal of research in her lab is to engineer viruses to treat diseases including monogenetic diseases,skin and  infectious diseases, and cancer. Our studies on oncogenic retroviruses of the lung and nasal epithelium have uncovered novel mechanisms of respiratory epithelial cell transformation and have identified unique targets for cancer treatment. Due to our interest in adeno-associated virus (AAV) and lentivirus gene therapy vectors for treating skin, liver and lung diseases, we have developed compact hybrid viral promoters with enhanced transgene expression in these tissues as well as identified novel AAV capsids from veterinary species and devloped uniquely engineered envelope glycoproteins for enhanced transduction in vivo.

DR. MAGDA FORSBERG, PHD

Scientific Advisor, Orthopedic Devices

Dr. Forsberg obtained her Ph.D. in animal development and epigenetics from Uppsala University in Sweden, and did a Postdoctoral Fellowship in Reprogramming and Neurobiology at the Karolinska Institutet in Sweden, and is the author of publications exploring fundamental aspects of cell biology. Dr. Forsberg, who became an Assistant Professor at the Karolinska Institute, Stockholm, has worked in the development of cell replacement therapy for neuro-degenerative diseases, focusing on stem cell biology, cell differentiation and clinical applications. Dr. Forsberg is currently President & CEO of DVL-op MEDICO Inc, based in Valencia, CA, involved in the production and commercialization of orthopedic and medical devices.

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