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Lactoferrin derived anti-scarring peptide

Håkansson J1, Mahlapuu M, Ekström L, Olmarker K, Wiig M., Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair. Hand Surg Am. 2012 (12):2519-25.


Nilsson E1, Björn C, Sjöstrand V, Lindgren K, Münnich M, Mattsby-Baltzer I, Ivarsson ML, Olmarker K, Mahlapuu M., A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat.  Ann Surg

. 2009,250(6):1021-8.


Wiig ME, Dahlin LB, Fridén J, Hagberg L, Larsen SE, Wiklund K, Mahlapuu M. , PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial. PLoS One. 2014 23;9(10):e110735. doi: 10.1371/journal.pone.0110735. eCollection 2014.

Scarring and adhesions

Dermal Scarring

Finnerty CC, Jeschke MG, Branski LK, Barret JP, Dziewulski P, Herndon DN., Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet. 2016 ;388(10052):1427-1436. Review


Lee HJ, Jang YJ., Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids. Int J Mol Sci. 2018 9(3). pii: E711. Review


Li-Tsang CW, Lau JC, Chan CC. Prevalence of hypertrophic scar formation and its characteristics among the Chinese population. Burns. 2005,31(5):610-6


Marshall CD, Hu MS, Leavitt T, Barnes LA, Lorenz HP, Longaker MT., Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions.,  Adv Wound Care (New Rochelle). 2018 7(2):29-45.


Post-operative adhesions

Awonuga AO, Fletcher NM, Saed GM, Diamond MP., Postoperative adhesion development following cesarean and open intra-abdominal gynecological operations: a review. Reprod Sci. 2011, (12):1166-85. Review



Baber Z, Erde MA, Failed back surgery syndrome: current perspectives. J Pain Research, 2016; 9 : 979—987


Lue JR , Boyd LS, Diamond MP, Pelvic Adhesive Disease: Current Approaches to Management, J  Womens Health Issues Care 2014,  ;44(3):405-20. . Review.   



Moris D,  Chakedis J,   Rahnemai-Azar AA, Wilson A,  Hennessy MM, Athanasiou A, . Postoperative Abdominal Adhesions: Clinical Significance and Advances in Prevention and Management, Journal of Gastrointestinal Surgery, 2017, 10: 1713–1722



Okabayashi K, Ashrafian H, Zacharakis E, Hasegawa H, Kitagawa Y, Athanasiou T, Darzi A., Adhesions after abdominal surgery: a systematic review of the incidence, distribution and severity. Surg Today, 2014, 44(3):405-20



Gene therapy


Gorell E, Nguyen N, Lane A, Siprashvili Z., Gene therapy for skin diseases., Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a015149. doi: 10.1101/cshperspect.a015149. Review.


Naso MF, Tomkowicz B, Perry WL 3rd, Strohl WR., Adeno-Associated Virus (AAV) as a Vector for Gene Therapy. BioDrugs. 2017, (4):317-334. doi: 10.1007/s40259-017-0234-5. Review.

Van Leshout LP, Domm JN, Rindler TN, Frost KL,  Sorensen DL, Medina SJ, Booth SA, Bridges JP,  and Wootton SK. A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice. Mol Ther Methods Clin Dev. 2018 Jun 15; 9: 323–329.

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