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Anti-Scarring Effect of Lactoferrin Derivative

​Preclinical

Håkansson J, Mahlapuu M, Ekström L, Olmarker K, Wiig M., Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair. Hand Surg Am. 2012 (12): 2519-25. https://journals.sagepub.com/doi/10.1177/1753193411410823

 

Nilsson E, Björn C, Sjöstrand V, Lindgren K, Münnich M, Mattsby-Baltzer I, Ivarsson ML, Olmarker K, Mahlapuu M A Novel Polypeptide Derived From Human Lactoferrin in Sodium Hyaluronate Prevents Postsurgical Adhesion Formation in the Rat

Annals of Surgery. 250(6):1021-1028, 20 https://insights.ovid.com/pubmed?pmid=19953722  

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Wiig M,  Dahlin L B, Fridén J, Hagberg L, Larsen SE, Wiklund K, Mahlapuu M., PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial. PLoS One. 2014 23;9(10):e110735. doi: 10.1371/journal.pone.0110735. eCollection 2014.https://lucris.lub.lu.se/ws/files/3843122/7525885

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​Clinical

PLOSOne 9(10) : e 110735 October 23, 2014

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207831/pdf/pone.0110735.pdf

​PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial

​Monica E. Wiig , Lars B. Dahlin, Jan Fridén, Lars Hagberg, Sören E. Larsen, Kerstin Wiklund,Margi Mahlapuu

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In a large multi center study in 138 patients anti-scarring peptide PXL-01 (enserptide)  caused  40-60 percent improvement of scarring related dysfunction  after hand surgery with repair of  raptured tendon.

 

Scarring and adhesions may reduce the mobility of fingers which compromises hand function and interferes with Activities of Daily Life.

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