ANTI-SCARRING GENE THERAPY
Anti-Scarring Effect of Lactoferrin Derivative
​Preclinical
Håkansson J, Mahlapuu M, Ekström L, Olmarker K, Wiig M., Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair. Hand Surg Am. 2012 (12): 2519-25. https://journals.sagepub.com/doi/10.1177/1753193411410823
Nilsson E, Björn C, Sjöstrand V, Lindgren K, Münnich M, Mattsby-Baltzer I, Ivarsson ML, Olmarker K, Mahlapuu M A Novel Polypeptide Derived From Human Lactoferrin in Sodium Hyaluronate Prevents Postsurgical Adhesion Formation in the Rat
Annals of Surgery. 250(6):1021-1028, 20 https://insights.ovid.com/pubmed?pmid=19953722
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Wiig M, Dahlin L B, Fridén J, Hagberg L, Larsen SE, Wiklund K, Mahlapuu M., PXL01 in sodium hyaluronate for improvement of hand recovery after flexor tendon repair surgery: randomized controlled trial. PLoS One. 2014 23;9(10):e110735. doi: 10.1371/journal.pone.0110735. eCollection 2014.https://lucris.lub.lu.se/ws/files/3843122/7525885
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​Clinical
PLOSOne 9(10) : e 110735 October 23, 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207831/pdf/pone.0110735.pdf
​PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled Trial
​Monica E. Wiig , Lars B. Dahlin, Jan Fridén, Lars Hagberg, Sören E. Larsen, Kerstin Wiklund,Margi Mahlapuu
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In a large multi center study in 138 patients anti-scarring peptide PXL-01 (enserptide) caused 40-60 percent improvement of scarring related dysfunction after hand surgery with repair of raptured tendon.
Scarring and adhesions may reduce the mobility of fingers which compromises hand function and interferes with Activities of Daily Life.